
Odette R. answered 07/03/21
MS in Biomedical Sciences | Medical Student | Teaching Assistant
Scenario A: A patient comes in with symptoms of fever, loss of appetite, a sore throat. You, the doctor, think that it might be a bacterial infection and prescribe antibiotics. The patient takes the antibiotics however the symptoms do not go away. What is the patient’s body doing to fight the disease?
During a bacterial infection, the body is initially attempting to fight using the innate immune response. The innate immune system contains many different defense mechanisms such as neutrophils, macrophages, cytokines, and the complement system. These components of the innate immunity will attempt to control the bacterial infection through inflammatory processes such as fever, muscle pain, and pus while the adaptive immune system can slowly develop a pathogen-specific response. This process can take multiple weeks after the initial exposure to the pathogen. Once the pathogen-specific antibodies are produced by B cells, they can begin their humoral response in the blood, tissues, and even secretions. Similarly, once T cells have been activated, they will exert their function. Helper T cells generate cytokines to modulate the immune response and Cytotoxic T cells actively kill the pathogen. However, it's important to note that Cytotoxic T cells play a major role in neutralizing viruses and cancer as opposed to bacterial infections.