
Brett C. answered 01/14/21
Experienced Filmmaker Specializing in History
When considering the collapse of the many Indigenous populations throughout the Americas during the Age of Exploration, many different images are evoked, from the rise of slavery within North and South America to the violent conquests led by the Spanish against the Aztecs and Incas. However, nowadays, we've all come to the conclusion that the most effective tool the conquistadors used in destroying these populations was not any physical weapon but a small, microbial weapon: Smallpox.
Although this was known at the time, and regularly used as a weapon by the Spanish, it was also considered somewhat insignificant by the conquistadors at the time, not realizing just how deadly the disease was to the unprepared Indigenous tribes. Due to this unawareness, Friar de Las Casas does not mention it being a direct tool of their downfall because, despite the use of "Smallpox blankets" and other disease spreading tools, the study of germs, infections, and viral outbreaks was much, much weaker than we have today.
Thus, the answer to this question would be A. The impact of European Disease.