Opposing pharmacological effects

Question

To what extent can agonists reverse antagonists? Is ir possible associated pathways don't return to their original behavior?

Answer 1

In theory, if the antagonist is a reversible antagonist, an agonist should be able to reverse the effect completely, given sufficient concentration of the agonist. It is possible that the pathways associated with the antagonism might not return to normal, but that's rather unlikely, especially in the long term.