Are chromosomes soluble when they are condensed?

Question

DNA is soluble, but are chromosomes still dissolved in the aqueous phase when they are condensed during cell division?

Answer 1

No, chromosomes are not soluble in aqueous solution. First, chromosomes are huge complexes. Secondly, the negatively charged backbone of DNA (phosphate group) is neutralized by the positively charged histones that a DNA complex wraps around in order to form a chromosome.