I have an enzyme that the enzyme-inhibitor complex requires 450 kJ.mol-1 to dissociate and that it displays kinetics somehow similar to non-competitive inhibition. are is a good inhibitor?

Question

Human xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. For the treatment of hyperuricemia and gout, several medications are used to inhibit the activity of xanthine oxidase and reduce the production of uric acid. You are a biochemist and just discovered a chemical that can inhibit the activity of the human xanthine oxidase. When analyzing its mode of inhibition, you found that the enzyme-inhibitor complex requires 450 kJ.mol-1 to dissociate and that it displays kinetics somehow similar to non-competitive inhibition. You sent your inhibitor to the ministry of health for approval as a medication for gout. Based on the data provided, are they going to authorize it as medication or not? Explain?

Answer 1

Yes I believe it will be a good medication of people suffering from gouts, the non competitive nature of the enzyme is what makes this attractive. Given that some one suffering from gout is producing abnormal amount of Uric acid is most cases a non competitive inhibitor makes more sense over competitive or uncompetitive inhibtiors