To ensure real coefficients, the complex conjugate of any complex zero must also be a zero. Therefore you must have at least 3 zeros:
2 - i
2 + i
f(x) = A(x + 2) [x - (2 - i)] [x - (2 + i)]
with A real, integer, and A ≠ 0. You can expand f(x) to standard form if you wish. The coefficients will come out real.