Does NADH inhibit gluconeogenesis?

Question

I was told in a physiology lecture that alcohol inhibits gluconeogenesis because 'NADH produced from ethanol catabolism leads to product inhibition'.But is NADH not a reactant coenzyme of gluconeogenesis? It would make more sense if NADH inhibits glycolysis by product inhibition.So, what is wrong here? Or is it because of some other reason why alcohol inhibits gluconeogenesis and leads to hypoglycemia?

Answer 1

Hi!

NADH does I inhibit gluconeogenesis! Alcohol leads to the increase in NADH over time. When this builds up it prevents the oxidation of lactose. Thus, excess ethanol will lead to hypoglycemia.

important note is that excess NADH would inhibit the whole TCA cycle!

Hope this helps!