03/16/19
İrreversible dopamine antagonist vs. Dopamine agonist?
Can a dopamine agonist reverse the effects of an irreversible dopamine antagonist?
03/16/19
Why does the weight matter when consuming a certain amount of a specific drug?
My question is actually referred to hallucinogenic substances, in particular to mushrooms.I can understand why alcohol or other substances that relate to body mass (fat in some cases) affect people...
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Do drugs' levo isomers have a better interaction with the receptors in our body than dextro isomers?
Examples of *levo* drugs include levothyroxine, levocitrizine, and levodopa. Is there any specific reason why the receptors in our body exhibit this stereoisomerism and hold a high preference for...
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03/15/19
Why is chemistry important?
03/15/19
Is the EC50 of an activating protein for an enzyme a good indicator for the binding affinity Kd?
We work with a membrane protein system where measuring the affinity between the enzyme and the upstream activating protein has been difficult, and when measured in detergent solution, it is almost...
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03/15/19
If x+1=17, what is x?
03/15/19
Relationship between toxicity of drugs and negative effects on brain?
Are psychoactive drugs with lower lethal doses more neurotoxic (more damaging to the brain)? For example, tetrahydrocannabinol (one of the active components of cannabis) has a much higher lethal...
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03/15/19
Enzyme Inhibition in relation to Aspirin?
I see that aspirin (in part) works by inhibiting cycloxygenase isoenzymes and that this inhibiting is irreversible. I've had a few classes mentioning this topic in passing, but never with depth.I...
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03/15/19
What is covalent bonding?
03/15/19
What is the mechanism behind "acquired" alcohol tolerance?
I can understand natural variation in alcohol dehydrogenase (ADH) in a population leading to variation in rate of inebriation (after controlling for other variables -- e.g., mass, food consumption,...
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03/15/19
How do drugs enter synapses?
Many psychopharmaceutical drugs change synapse chemistry or directly agonize neuroreceptors in the brain. For example, cabergoline is a D2 agonist.How do these compounds enter the physical...
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03/15/19
Why should we preceed neostigmine by atropine in tubocurarine toxicity?
Why should we precede neostigmine by atropine in tubocurarine toxicity ?I know that neostigmine act as anticholinesterase thus increasing the number of Ach molecules rendering them able to displace...
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