Do drugs' levo isomers have a better interaction with the receptors in our body than dextro isomers?

Question

Examples of *levo* drugs include levothyroxine, levocitrizine, and levodopa. Is there any specific reason why the receptors in our body exhibit this stereoisomerism and hold a high preference for the *levo* isomer form of any drugs?

Answer 1

Amphetamine works better as the d-isomer, for example. So, as mentioned by Matthew P., there doesn't seem to be a correlation between rotation and biologic activity.

Answer 2

I don't think there's a obvious correlation between the direction that a molecule rotates plane polarized light, and it's biological activity. There are some drugs and molecules that are more active as their dextrorotatory enantiomer. Levorotatory glucose, for example, cannot be processed for energy. I read somewhere it was considered as an artificial sweetener, but it was too expensive to make.