Hi Sarah,
While we know the true population mean and standard deviation, to get the comparison, we have to use the sample mean and standard deviation to get the confidence interval. We know data are normally distributed and we know a population standard deviation, even though we don't use it, so we use a z-confidence interval:
CI= xbar +/- z* SE
xbar=sample mean
z*=z-critical value
SE=s/sqrt(n)
s=sample standard deviation
n=sample size
Now, a 95% confidence interval is sufficient in most cases, and I don't know any difference in the medical world, so we'll use that. You can get the critical value from a z-table, but it is probably better to just memorize the most common:
90%: 1.645
95% 1.96
99%: 2.576
So, for our problem:
xbar = 15
z* = 1.96
s=3
n=100
SE= 3/sqrt(100)
SE=3/10
SE=0.3
CI= 15 +/- (1.96*0.3)
CI = (14.412, 15.588)
Is 12 in this interval? No. That means there is significant difference between sample mean and population mean. Be sure to specify that you used 95% confidence. I hope this helps.