You can put 4x + 3y = 21 into Slope Intercept form as follows
3y = -4x + 21
y = (-4/3 )x + 7
The line above has a slope, m
m = (-4/3)
A line perpendicular to it would have a slope, m = (-1/m) where
(-1/m) = 3/4
In slope intercept form
y = (3/4)x + b
We can use the coordinates (4,2) to calculate b
2 = (3/4)(4) + b
2 = 3 + b
2 - 3 = b
-1 = b
The perpendicular line in Slope Intercept Form is
y = (3/4)x - 1
You can graph these lines a Desmos.com