Mandeep K.

asked • 12/29/19

I need help with understanding structural activity relationship of modified compounds.

I synthesized peptoid or mimics of Wollamide a TB antibiotic. I’m seeking to determine the structural activity relationship and understand stereochemistry of each compound. I need to know what’s the mechanism of action of my compound given the modifications. I have an idea regarding the MOA, since wollamide is a cationic antimycobacterial cyclohexapeptide that exhibits activity against Mycobacterium bovis. If a cyclic peptide inhibits protein synthesis 50s of ribosome. Is it safe to assume wollamide can diffuse through the cell membrane and inhibit protein synthesis?

1 Expert Answer


Jesse E. answered • 12/30/19

Experienced Biochemistry Tutor

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