
Robert H. answered 02/21/21
Web Designer with 6+ Years of E-Commerce Experience
Yes, they can!
I've worked mostly with Bootstrap and Flexbox over the last handful of years. Flexbox (used in Bootstrap 4+) has a great structure and allows quick changes for all screen sizes. I find flexbox easier to visualize compared to CSS grid. But I have seen how powerful the CSS grid is.
Here is an example of how they could potentially work together (I'll use Bootstrap 4 syntax):
This example would essentially use Bootstrap's flexbox to set up the layout of this container and the CSS grid would control the .parent, .main, and .sidebar classes within the col-8 div. The CSS grid styles would take over within the col-8 div only.
Hopefully, that clears up your question.
Please let me know if you have any others,
Robert Hogan