John C. answered 08/28/21
Ancient and Modern European History tutor
One of the primary issues that affected the predominantly one-way direction of disease transmission between Europeans and native peoples was that European societies had grown dense. High population density can more readily lead to disease mutation and subsequent exposure, creating an evolving loop between the disease and antibodies. These evolving diseases can become quite effective at attacking immune systems. When introduced to native populations who had never encountered such a disease before, the disease found no antibodies to counteract its attack. Furthermore, the Europeans had a great deal of cultural contact and transmission through trade (additionally driven by early principles of an emerging paradigm called capitalism), which exposed large swathes of Europe to similar diseases -- consider the bubonic plague as the foremost example. The scale of contact between pre-colonization American civilizations was less than that of European civilizations, providing buffers between the major peoples (Mayan, Aztec, Incan). While these cultures had several large cities of note with high levels of sophistication and high population density, these cities were fewer in number and had less interaction between one another than European cities. Finally, the Europeans did suffer from several novel diseases, infections, etc in the Americas, but they weren't of the highly-communicable variety that so effectively ravaged the native peoples (think yellow fever, for instance, which is spread through mosquitoes).