Administration of epinephrine with a local anesthetic may result in the reduction of arterial diastolic blood pressure due to stimulation of what receptor?

Answer 1

Most Vascular smooth muscle cells express a1 receptors. But skeletal muscle vessels and coronary arteries express b2. at low concentration of epinephrine beta 2 dominates because they have higher affinity for epinephrine than alpha 1.

β2 receptor stimulation in skeletal muscle arteries → vasodilation → ↓ peripheral resistance → reduced diastolic blood pressure.



Answer 2

Administration of epinephrine with local anesthetics may result in a reduction in diastolic arterial pressure due to the stimulation of Beta-2 adrenergic receptors. This mechanism, along with Beta-1 mediated tachycardia, can warn of intravascular injection of local anesthetic.