Thomas R. answered 01/05/20
Over 25 years of experience and a sense of humor about math
Ah, this is a fascinating question! The problem is that the constitution says nary a word about the position of minority or majority leaders in either chamber; these positions were created less than a century ago, according to the senate's website:
https://www.senate.gov/artandhistory/history/common/briefing/Majority_Minority_Leaders.htm
The senate does have official rules written and voted on by its members, which you can read here:
https://www.rules.senate.gov/rules-of-the-senate
They are managed by the Senate Parliamentarian, a person whose job is to ensure that the Senate follows its own rules. The biggest catch to removing a majority leader is that they are answerable only to their own party, and so can only be removed by that party. That has never happened in American history. Leaders have passed away and been replaced, but no Senate Majority Leader has even been brought low by their own party while serving. Also, if a party gains the majority after time spent in the minority, they have been known to select a new leader.