Can the liver prioritize its metabolizing potential?
Let's assume we have two toxins - one of which is routinely metabolized by the liver, and the other is new to the organism (consider for example alcohol in a heavy drinker and any other drug that is taken for the first time) and they are administered at once. Does the liver have any way to prioritize metabolizing either of these substances or does it happen simultaneously for both?
The answer is it happens simultaneously. This is one reason why we would not administer 2 drug that are competing with the CYP4 at the same at. We would give them like 2-4 hours apart.
