The equation of a line is y = mx + b, where m is the slope and b is the y-intercept (the point where the line crosses the y-axis). The problem gives you the slope, m = -2. So the equation so far is:
y = -2x + b
To find b, plug in the x,y values of the given point, (4,-3), into y = -2x + b:
-3 = -2*4 + b
-3 = -8 + b
Solve for b, then plug the value you get into the equation y = -2x + b in place of the b and you're done.