dosage calculations

Question

the recommended dose for midazolam is 0.07 to 0.08mg/kg IM one hour before surgery. It is available as 5mg per mL and must be given in exact dose. How many mL should be injected into a 182-pound patient? Round off to nearest one tenth of a mL.

Answer 1

The stock solution is 5 mg/mL

Now we want our solution as mL/kg so we can multiply it by our patient's weight to find out how many mL he/she should receive. To do this, we must divide our dose by the stock concentration: 

Lower limit: 0.07 mg/kg ÷ 5 mg/mL = 0.014 mL/kg

Upper limit: 0.08 mg/kg ÷ 5 mg/mL = 0.016 mL/kg

 

Now we multiply by our patient's weight in kg which is:

182 lbs ÷ 2.2 lbs/kg = 82.73 kg

 

Lower limit: 0.014 mL/kg * 82.727 kg = 1.158 mL

Upper limit: 0.016 mL/kg * 82.727 kg = 1.324 mL

 

So what should be injected is 1.2 to 1.3 mL