Looking at the difference formula for tangent: tan(α-β)=(tan(α)-tan(β))/(1+tan(α)tan(β))
What this formula tells us is that if we know the tangent of α and β, we know the tangent of α-β. Further, we know that tangent=sine/cosine. This means if we can figure out the sine and cosine of both α and β, we can figure out the answer.
The problem says that cos(α)=(√7)/4 and sin(β)=(√10)/6. So, if we can figure out sin(α) and cos(β), we have all the pieces to plug in to the difference formula.
To find sin(α), let's use the fact that cos^2(α)+sin^2(α)=1, or re-arranged: sin(α)=√(1-cos^2(α)) = √(1-7/16)=√(9/16)=3/4. We know to use the positive square root rather than the negative root since the angle is in the first quadrant according to the problem - therefore the sine is positive.
We can use the same trick to find cos(β)=√(1-sin^2(β)) = √(1-10/36)=√(26/36)=(√26)/6.
Now, tan(α)=sin(α)/cos(α) = (3/4)/((√7)/4)=3/√7 = (3√7)/7.
And: tan(β)=sin(β)/cos(β) = ((√10)/6)/((√26)/6)=(√10)/(√26)=(√65)/13.
We now have everything we need to do the difference formula at the top:tan(α-β)=((3√7)/7-(√65)/13)/(1+((3√7)/7)((√65)/13)), which simplifies to (27√(7)-8√(65))/23.