Bill B. answered 03/05/21
Bill Art, Guitar, French, and Excel Tutor
I am not sure if you are playing only chords or if you are playing some single-note melody in between the chords. But if you are playing chords and melody then that can help make up your mind. If the melody you are playing lends itself to playing the chord with root on the 6th string rather than the 5th string, then that narrows down the possibilities.
Also, mixing up the chords from one verse to the next adds extra flavor to a repetitive chord progression. Try playing the same progression in first position. And then try it in fifth position for example. Can you play the same progression at the 12th fret (that is an octave higher than the first fret). Make it more compelling for your listeners and also more interesting for yourself that way.