Nicole L.
asked • 07/12/20the fraction saturation of myoglobin at 30 mm Hg and 100 mM Hg, the partial pressure of O2 in venous and artery blood
PO2: YO2:
0.5 0.161
1 0.277
2 0.434
3 0.535
4 0.605
6 0.697
8 0.754
12 0.821
20 0.885
More
1 Expert Answer
The fraction of myoglobin saturation with oxygen (Y) can be calculated using the Hill equation for myoglobin, which is simplified as the Michaelis-Menten equation because myoglobin binds oxygen with a 1:1 stoichiometry:
Y=pO2pO2+P50Y=pO2+P50pO2
Where:
- YY is the fractional saturation of myoglobin.
- pO2pO2 is the partial pressure of oxygen.
- P50P50 is the partial pressure of oxygen at which myoglobin is 50% saturated (approximately 2.8 mm Hg for myoglobin).
Given:
- pO2pO2 = 30 mm Hg (venous blood)
- pO2pO2 = 100 mm Hg (arterial blood)
We can calculate the fractional saturation for each partial pressure.
For pO2=30pO2=30 mm Hg:
Y=3030+2.8Y=30+2.830 Y=3032.8Y=32.830 Y=0.915Y=0.915
For pO2=100pO2=100 mm Hg:
Y=100100+2.8Y=100+2.8100 Y=100102.8Y=102.8100 Y=0.973Y=0.973
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Stanton D.
Hi Nicole L., This question is spartanly stated. PaO2 = 75 - 100 mm Hg, PvO2 = 30 - 40 mm Hg . The table appears to be saturations of myoglobin, at various PO2 levels. Myoglobin sucks O2 up nicely. Do you need a math fit for your myoglobin data to estimate 30 and 100 mm saturations? Since this is a straight equilibrium uptake, graph 1/YO2 vs. 1/PO2 . Has intercept 1 and slope K, where K is the dissociation constant. Check out P50_(pressure) on W.i.k.i.p.e.d.i.a -- Cheers, -- Mr. d.07/14/20