This is a typical AP style question where you can answer it either way if you are able to defend yourself but generally this would be thought of as leading to secession. If you want to go in favor of it leading to secession, you could use the following three points:
- Slave states were upset by the addition of a large free state
- Banning slave trade in Washington DC
- neither antislavery senators nor firewaters would vote yes on the bill
To argue that it prevented secession (again, I'd probably go the other way, but if you're reviewing for the AP test you could ultimately get points if you're able to defend yourself)
- Even when the bill was "unbundled" (all the measures were voted on separately) the bill passed, showing widespread support
- There were elements meant to appease both parties, such as the admittance of CA as a free state and the new Fugitive Slave Law
- new boundary between TX and Mexico was generally popular --> good sentiments