the half-life of vancomycin is 3 hours. You inject a bolus of 2000mg into this patient. How long will it take for the blood vancomycin concentration to be less than 10mg/ml

Question

A 26-year-old female with a history of IV heroin use (most recent use within 24 hours before admission) presents to the ED with fever and malaise. Upon exam she is clinically unstable and persistently febrile (T=39 deg, BP 70/40, heart rate 118). A sepsis protocol is started and you order IV fluids and broad spectrum antibiotics, including the glycopeptide antibiotic vancomycin. The patient weighs 58 kg, serum creatinine clearance is 0.6mg/dl, height 170cm.

the half-life of vancomycin is 3 hours. You inject a bolus of 2000mg into this patient. How long will it take for the blood vancomycin concentration to be less than 10mg/ml

Answer 1

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