
Douglas G. answered 03/29/19
M.A. Degree + 25 Years' Teaching Experience
I don't know whether I'd call it foreshadowing or dramatic irony -- or some mixture of both. While there's not a lot that shows Lady Macbeth going insane, she ironically chastises Macbeth for acting in such a way that he will go insane.
Right after reading her husband's letter in Act I, scene v, LM "prays" to the spirits to have her conscience essentially turned off: "Stop up the access and passage to remorse / That no compunctious visitings of nature / Shake my fell purpose."
Later (Act II, scene ii), when Macbeth expresses regret for having Duncan's blood on his hands, she warns him that talking about his guilt will drive him mad: "These deeds must not be thought / After these ways; so it will make us mad."
When she returns to their chamber after smearing Duncan's blood all over his grooms, they wash their hands and prepare to meet whoever it is knocking at the gate. She naively tells Macbeth, "A little water clears us of this deed." Of course, the irony is that -- in her madness -- she is continually washing her hands, which will never ever be clean again.