Mark M. answered 04/27/18
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Retired math prof. Calc 1, 2 and AP Calculus tutoring experience.
F(x) = ∫(from 0 to 2x) tan(t2) dt
By the Fundamental Theorem of Calculus, F'(x) = tan((2x)2)(2x)'
= 2tan(4x2)
So, F"(x) = 2sec2(4x2)(8x) = 16xsec2(4x2)
Therefore, F"(1) = 16sec2(4) ≈ 37.449