Will N. answered 06/03/15
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This is a difference of squares, since 16x2y2=(4xy)2
A difference of squares factors as a2-b2=(a+b)(a-b). In this problem, a=x+9y and b=4xy, so this comes out as
(x+9y+4xy)(x+9y-4xy)
I hope this helps.
Vincente M.
06/03/15