The problem is to minimize the distance between the two lines.
Let A ( 2-2t ,-4t ,2+5t ) be a point on the first line and
B ( 4+3s, 5+5s, -4+4s ) a point on the second line.
Then their distance D (s, t) = { (2+3s+2t)2 + ( 5 +5s+4t)2 +(6+5t-4s)2 }1/2 ( Equation I )
To minimize D suffices to minimize d (s,t) = (2+3s+2t)2 + ( 5 +5s+4t)2 +(6+5t-4s)2
∂d/∂s =14 + 100s +12t
∂d/∂t = 108 +12 s + 90t
Solving the system of equations ∂d/∂s =0 and ∂d/∂t = 0 we get ( s , t ) = ( 1/246 , -443/369 ).
Substituting the values of s and t back in to Equation I we get the smallest distance between the lines
being 7 √246 / 246.

Adam B.
08/03/21
Sude B.
Thank you for your help. I'll be glad if you help me with my other questions.08/03/21