By parts.
First you choose a u (which gets differentiated) and a dv/dx (which gets integrated).
If we choose x³ to get integrated, we'd repeatedly increment the exponent of x without getting anywhere. If we choose ex²-3 to be integrated, well, that function doesn't have an elementary integral.
But, there are other ways to factor that. For example, even though ex²-3 doesn't have a nice clean integral, its derivative, 2xex²-3, does. And our expression most certainly does factor out xex²-3 (the 2 is just a constant out front).
So, we choose dv/dx = 2xex²-3, and u = 2x².
∫ u * dv/dx dx = u*v - ∫ du/dx * v dx
∫ 2x² * 2xex²-3 dx = 2x² * ex²-3 - ∫ 4x * ex²-3 dx = 2x²ex²-3 - 2 * ex²-3 + C
So ∫ 4x³ex²-3 dx = 2(x²-1)ex²-3 + C
Just to check, let's differentiate it:
d/dx 2(x²-1)ex²-3 + C = 2(2x)(ex²-3) + 2(x²-1)(2xex²-3) + 0 = (4x+4x³-4x)ex²-3 = 4x³ex²-3
Yup, it works out.