Let L and W represent the length and width, respectively, of the rectangle. The perimeter P = 2(L + W), and since the area is 100 in2 we have 100 = LW, or W = 100/L. Therefore P = 2(L + 100/L). Completing the square,
P = 2[L - 20 + 100/L + 20] = 2[(√L - 10/√L)2 + 20] = 2(√L - 10/√L)2 + 40
So the perimeter P is at least 40 in, and equals 40 in exactly when √L = 10/√L, i.e., L = 10 in. So the minimum possible perimeter is 40 in (when the rectangle is a square).