To find a directional derivative, we find the gradient at our point of interest, then take the dot product of that gradient and the direction we're going. For this problem:
∇f=<∂f/∂x, ∂f/∂y> = <e4y-3ye3x, 4xe4y-e3x>
At point (2,2), ∇f=<e8-6e6, 8e8-e6>
Now we take ∇f•v = ( e8-6e6)*-2 +(8e8-e6)*3 = 6e8 + 11e6, and that's our answer!
I hope this made sense, good luck in your Calculus class, and don't be afraid to message me if you need any more help!