Mark M. answered 11/22/18
Retired math prof. Calc 1, 2 and AP Calculus tutoring experience.
F(x) = ∫(1 to x) f(t)dt
By the Fundamental Theorem of Calculus, F'(x) = f(x). So, F"(x) = f'(x).
f(t) = ∫(1 to t2) [ √(4 + u2) / u ]du
f'(t) = [√(4 + t4) / t2] (t2)' = 2√(4 + t4) / t
So, f'(2) = 2√20 / 2 = 2√5
Therefore, F"(2) = f'(2) = 2√5