Hi Shelby B.
Since I don't see a selection of expressions to choose from for you, I suggest that you do the following;
Factor the Numerator
Factor the Denominator
Cancel as applicable
Then select from your possible list choices
I've done most of it for you below
4x^2 - 8x - 5/4x^2 - 25
(2x + 1)(2x - 5)/(2x -5)(2x +5)
Can you continue from above to get a final expression?