Sketch the problem so David drives to the left and Amy drives to the right.
Initially David and Amy are 435 miles apart. As both drive toward each other, the combined distance traveled will eventually equal to 435 miles at the point where they meet.
Distance = speed x time
The different starting time adds a bit complexity to the problem, so we need to express the amount of time Amy drives as 2 hours less than the amount of time David drives.
So for David, the distance he travels to the meeting point is 60 x T
For Amy, the distance she travels to the meeting point is 45 x (T-2)
Adding these 2 expressions 60T + 45(T-2) = 435. then solve for T ; 105T - 90 = 435 ; T = 525 / 105 = 5
Hence David drives 60x5 = 300 miles to the meeting point (Amy drives 135 miles).