In conducting analyses between pairwise comparisons of multiple variables in clinical trials, should clinical researchers use a p-value that is more conservative than 0.05?

Answer 1

A correction factor to the p-value should always be applied to account for error that accumulates by making multiple consecutive comparisons. There are several methods for doing this. Whatever statistical software you favor likely has one included. Look for names like Tukey or Bonferroni, they are some of the most common methods.