Can an antipyretic (I.e. Aspirin) lower normal body temperature?

Question

Is it possible for an antipyretic medication taken when not experiencing fever to cause a person's body temperature to drop below normal? I found [one article](http://www.ncbi.nlm.nih.gov/pubmed/7976349) that seems to say yes, but only for large doses (in mg/kg) in mice.

Answer 1

In theory, yes. But, it would be really difficult. You would probably be more concerned about internal bleeding or other really horrible effects from overdosing than your temperature.