Asked • 03/27/19

Can an antipyretic (I.e. Aspirin) lower normal body temperature?

Is it possible for an antipyretic medication taken when not experiencing fever to cause a person's body temperature to drop below normal? I found one article that seems to say yes, but only for large doses (in mg/kg) in mice.

Omer A.

tutor
Yes Aspirin does lower the bodys temprature by causing a decrease in the production of Prostaglandins. This is because Aspirin irreversibly acts to inhibit the COX 1 and 2 enzymes leading to sequential inhibition of prostaglanding production. One type of prostaglandin known as PGE2 is a pyrogen that acts to elevate the hypothalamic set point causing fever. Aspirin inhibits this prostaglandin and hence,is an antipyretic.
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02/22/20

1 Expert Answer

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Ari B. answered • 01/04/23

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