The equation is in slope intercept form, and the slope is 1/6.
The slope of the line perpendicular to a line with a slope of 1/6 will be -6. You haven't provided a target point that must be included in the perpendicular line. Therefore any line of the form y = -6x + b will be perpendicular to the line y = 1/6 x + 4.
The slope of the perpendicular is the opposite of the reciprocal of the original slope. Simply flip it and change the sign.