Thank you for posting your question!
A major difference between them is their viewpoint on the role of the government in the economy ... Mercantilists advocated for policies like tariffs and subsidies that involved substantial government intervention in the economy. Adam Smith was more in favor of a free market approach, meaning that it is important for there to be free markets and limited government intervention.
I hope that gets you moving in the right direction on this question! Feel free to reach out via message if you have any additional questions beyond that! :)