Ilyas I.

asked • 04/12/21

Pharmacokinetics

1.) A patient is receiving multiple iv bolus doses, 720 mg every 12 hr. Steady-state peak and trough concentrations are 25 mg/L and 14 mg/L, respectively. Calculate the patient-specific CL and V for this drug in this patient.

2.) a patient is receiving an iv bolus dose regimen, 720 mg every 12 hr. The therapeutic window for this drug is 10 mg/l to 20 mg/l. the patient's steady-state peak and trough concentrations are currently 25 mg/l and 14 mg/l, and the patient has signs of toxicity. which of the following dosage regimens would be most appropriate?

3.) A drug with a therapeutic window of 5 mg/l to 10 mg/l will be administered as multiple iv bolus doses. The drug has the following pharmacokinetic parameters: V=50 L and CL=8.6 L/hr. what dose rate (X^0/T) would you recommend to produce an average steady-state concentration of 7.5 mg/L.


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Brian L. answered • 10/21/23

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Brian L.

I made an incorrect statement when I said “all of the drug is in the plasma immediately after an IV bolus dose” when I was describing how to calculate volume of distribution from Cmaxss and Cminss. Many drugs are not confined to the plasma compartment; the volume of distribution is basically proportionality constant that relates the amount of drug administered to the concentration of drug in the plasma. It does not describe an actual physiological volume (i.e., plasma volume).
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10/24/23

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