Asked • 06/24/19

Clemmensen reduction vs. Wolff-Kishner reduction?

In which cases is the Clemmensen reduction is preferred over the Wolff-Kishner reduction? One thing is that the Clemmensen reduction is done under acidic conditions whereas the Wolff-Kishner reaction is done under basic condition, and that I think decides somewhat which to choose depending of the nature and other groups present in the reactant. But are there any other points to keep in mind while choosing the best suitable reaction?

1 Expert Answer


Matthew P. answered • 07/07/19

5.0 (768)

Tutor Specializing in Organic and General Chemistry

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