Mark M. answered 10/28/18
Retired math prof. Calc 1, 2 and AP Calculus tutoring experience.
F(x) = integral (from 1 to x) f(t)dt
By the Fundamental Theorem of Calculus(FTC), F'(x) = f(x). So, F"(x) = f'(x).
But, f(t) = integral (from 1 to t^2) [sqrt(1+u^2) / u]du
Again, using the FTC, f'(t) = (sqrt[1 + (t^2)^2] / t^2) (t^2)' = 2 sqrt[1 + t^4] / t
So, F"(2) = f'(2) = 2sqrt(17) / 2 = sqrt(17).