Samagra G.

asked • 07/01/16

name of drug

Acetone reacts with CHCl3 in presence of KOH to form a sleep inducing drug . What is the name of drug and what is the mechanism of the reaction ?

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Stephanie C. answered • 07/02/16

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The drugs name is trichloro-2-methyl-2-propanol and it is produced by nucleophilic addition in basic conditions.
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Samagra G.

can you please show me the mechanism
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07/03/16

Stephanie C.

The base pulls off the acidic proton of the chloroform, making it a strong nucleophile. That attacks the electrophilic carbon of the ketone. The oxygen becomes negatively charged and then picks up a proton in the workup.
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07/03/16

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