Hi, Regina.
The order of operations remains the same for positive and negative numbers: Parentheses, Exponents, multiplication/division, and addition/subtraction.
When you multiply and divide postiive and negative numbers:
a positive times/divided by a positive gives a positive answer
a positive times/divided by a negative gives a negative answer
a negative times/divided by a negative gives a positive answer
Another way to say it is that in multiplication and division, two of same signs gives a positive answer, two different signs give a negative answer. The multiplication or division part of it doesn't change.
So for your problems:
-2 x 4 = -8 (negative two times positive four = negative eight)
-4 x 3 = -12 (negative four times positive three = negative twelve)
-2 divided by 6 = -2/6 which reduces to -1/3
Hope this helps!