Elena K. answered • 08/15/19
Clinical training, PhD, professor, well published author (70+ papers)
Dihydrofolate reductase (DHFR) is an enzyme that catalyzes reduction of the dihydrofolate to tetrahydrofolate during folate metabolism in malaria parasite. Dihydrofolate reductase inhibitors interfere with a pathway of folate metabolism, essential to malaria parasite survival. This involvement of dihydrofolate reductase in malaria parasite folate metabolism makes the enzyme a valuable target for the therapeutic agents
Richa Mishra, Brijeshkunvar Mishra and N.S. Hari Narayana Moorthy , 2006. Dihydrofolate Reductase Enzyme: A Potent Target for Antimalarial Research. Asian Journal of Cell Biology, 1: 48-58.
