Factors SN1 SN2 E1 E2
nucleophile: any(often weak) ; good, strong
base: any (often weak) ; must have strong
substrate 3>2 ; methyl > 1 > 2 ; 3 > 2 ; 3 > 2> 1
leaving group: good; conjugate base of stong acids --------------------------------------->
solvent: polar protic ; depends on ; good ; wide variety
nucleophile: any(often weak) ; good, strong
base: any (often weak) ; must have strong
substrate 3>2 ; methyl > 1 > 2 ; 3 > 2 ; 3 > 2> 1
leaving group: good; conjugate base of stong acids --------------------------------------->
solvent: polar protic ; depends on ; good ; wide variety
(maybe aprotic) what you want ionizing
Characteristics
kinetics: 1st order k[R-X] ;2nd order k[R-X] [Nu:] ;1st order k [R-X] ; 2nd order k[R-X] [B:]
stereochemistry: racemic ; inversion ;Zaitsev ; Zaitsev
rearrangement: common (2 --> 3) ;impossible ;common (2 --->3) ; impossible
orientation: ; none ; anti (180)
Comments