Asked • 01/20/20

Explain the role of

Question: Explain the role of glutamate and AMPA/NMDA receptor interaction in the promotion of pyramidal cell excitability, accompanied by spine formation, in the hippocampus.

1 Expert Answer


Jamie B. answered • 01/20/20

Science / Math Communicator (Professional Academic Freelance Editor)

Jamie B.

PART II Now then--WHAT IS EXCITABILITY IN A PYRAMIDAL CELL--I suppose we are talking basics-- The NMDA ("glutamate") receptors 'stimulate' 'result in' excitatory post synaptic potentials---versus inhibitory psp which is reg'd by GABA system subst'd aminobutyric acids versus substd' aminopropionic acids ---note These root-looking dendritic tree - structures in the brain, composed of elongate cells called neurons--do essentially one thing each. They pulse or they do not-- (they may pulse repetitively so two things?) What determines whether they pulse? Whether the sum of inputs and outputs is instantaneously passed a threshold called appropriately ACTION POTENTIAL A potential as 'like' a volt; rather a volt is a unit of electrical potential. There is gravitational potential---that is how far from gravity center you are---why? Higher potential location possess potential energy--in gravity case--to Fall literally; in other cases, to fall down the curve To accelerate, to do work , etc. If you are a charged particle and you are in an electric field----it is similar to a particle with mass being in a gravity 'field'--you accelerate based on simple rules---accelerate means force, work..... energy is the accounting term; potential has a more intuitive feel One way potential/pulses propagate is a nonlinear system thing--back propagation through dendrite, it's like an amplitude limiting feedback ANY WHOO- The specific method of excitatory input we are talking here is initiated by local input from NMDAR activated (for instance by NMDA) ion channels.... well relatively slow---deactivation is fast--cell eats up shoots out deals with those ions not like in round bottom flask--- Flood of ions increases potential.... yada yada--- NOW as to modern research--I am not well aware--only peripherally of the research into "OLD" idea of plasticity with newfangled aims. One thing glutamate receptor system is WELL KNOWN for--is involvement in emotional and stress responses..... my guess is it is more of the same--here activation does this; there it does that; oh btw paradoxically an antagonist will do the same as an agonist when this and that---wd have to look into it. DID YOU GET ANY OF THAT? NOT IMPORTANT DID YOU GET ANYTHING OUT OF IT HOPE SO VERY BROAD QUESTION BTW


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